Applications of LC-MS in Toxicology

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Applications of LC-MS in Toxicology

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Applications of LC-MS in Toxicology

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Aldo Polettini (ed)
Published by
Pharmaceutical Press
Publication Date
June 2006
304 pages
189 x 246 mm

Applications of LC-MS in Toxicology gives practical hands-on information on applications of LC-MS on different groups of drugs and poisons, and in different contexts.

This book covers all essential theoretical aspects of liquid chromatography coupled with mass spectrometry including:
  • technical details of the instrumentation
  • method development
  • optimisation and validation
  • quantification
  • maintenance
  • troubleshooting.

Further chapters cover in detail the application of LC-MS in areas such as
  • systematic toxicological analysis
  • drugs of abuse
  • therapeutic drug monitoring
  • doping in sport
  • pesticides
  • peptides
  • further potential forensic applications.

Following the developments of LC-MS in the last decade and its establishment as the method of choice in the pharmaceutical industry, the technique is increasingly being used in other scientific disciplines, including analytical toxicology.

This authoritative text is essential reading for all forensic and clinical toxicologists and will also be useful to pharmaceutical analysis as well as analytical chemists. 
  1. Ionisation, Ion Separation and Ion Detection in LC-MS
  2. Method Development and Optimisation of LC-MS
  3. Quantification Using LC-MS
  4. Method Validation Using LC-MS
  5. Identification and Confirmation Criteria for LC-MS
  6. Systematic Toxicological Analysis with LC-MS
  7. Analysis of Therapeutic Drugs with LC-MS
  8. LC-MS of Drugs of Abuse and Related Compounds
  9. LC-MS in Doping Control
  10. Pesticide Analysis Using LC-MS
  11. LC-MS in Forensic Chemistry

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