Molecular Biopharmaceutics

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Molecular Biopharmaceutics

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Molecular Biopharmaceutics
Aspects of Drug Characterisation, Drug Delivery and Dosage Form Evaluation

 RRP: £135.00
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Bente Steffansen, Birger Brodin and Carsten Uhd Nielsen
Published by
Pharmaceutical Press
Publication Date
November 2009
392 pages
156 x 234 mm

Molecular Biopharmaceutics focuses on describing the interplay between the chemistry of drug molecules and membrane transporters. The book guides researchers in setting up experiments that help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.

Starting with an introduction to the topic, it then considers the following:
  • physico-chemical characterization of drug candidates
  • membrane transport of drug candidates
  • describing and predicting bioavailability.

Molecular Biopharmaceutics covers a complex and developing academic scientific area, comprehensively encapsulating the essentials of the topic. It is also of increasing importance in drug development.

The book will be an invaluable resource for postgraduate pharmaceutical science students, biopharmaceutical scholars, scientist within academia and pharmaceutical scientists. 
Part 1 Introduction to Molecular Biopharmaceutics
Part 2 Drug Characterization and Preformulation
  1. Pka, Solubility, Liphophilicity and Solid State Characterization of Drug Candidates
  2. Stability of Drug Candidates in Aqueous Solutions
  3. Kinetics of Acid, Base and Enzyme Catalyzed Hydrolysis
  4. Chemical Approaches to Improve Drug Delivery and Formulation of Drug Candidates
  5. Preformulation:
Part 3 Drug Delivery Across Biological Membranes
  1. Biological Membrane Structures
  2. Diffusional Permeation of Drug Candidates
  3. Carrier Mediated Transport Kinetics
  4. Classification of Human Membrane Transporters
  5. Absorptive Transporters
  6. Efflux Transporters
  7. Preclinical Evaluation of Drug Transport
Part 4 Dosage Form Evaluation
  1. In Vitro Drug Dissolution
  2. Biopharmaceutical Classification System
  3. Biosimulation Studies
Part 5 Conclusions and Future Perspectives

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